Entirely Non-Smoking Lodging:

Holiday Inn Express & Suites Sioux Falls Southwest 3821 West Avera Drive Sioux Falls, South Dakota 57108 866-676-3077 To Book This Hotel Map Welcome to our Sioux Falls Southwest Hotel, the newest hotel in town! Welcome to Sioux Falls, the largest city in South Dakota. With Sioux Falls being the retail and medical hub in our state, our hotel is located right where you want to be! With easy Interstate access off of I-29 and I-229, our hotel is not only easy to find but is minutes from the Empire Mall for your shopping experience. Corporate guests looking for hotels in Sioux Falls, SD need look no further than this Holiday Inn Express & Suites hotel which offers a state of the art business center, free fast high speed Internet, an expanded fitness facility with Precor equipment, and 900 square feet of meeting space. We are just a short drive from businesses like the Avera Heart Hospital and Corporate offices, Midland National Life Insurance, McHale Institute, Missouri River Energy Services, and Colorado Technical University. Families can enjoy a stress free trip when they stay with us in Sioux Falls, SD. At our hotel, we pride ourselves in providing you with a great location closest to the most popular attractions, including the Sertoma Butterfly House and Wild Water West Amusement Park. Our hotel has a large pool area including a children's splash pool for our younger guests! Make your reservations today and enjoy our upscale hotel property during your next Sioux Falls visit! While here, check out Falls Park, our city's namesake! This is an entirely non-smoking hotel. Click through for more information or to book.